Drug absorption after ingestion depends on
the solubility of the tablet or capsule under the physological
condition and the permeability of the drug across the gastro
intestinal tract. The in Vitro dissolution studies are used
for prediction of in vivo drug absorption performance.
AAL has several dissolution systems for immediate
and slow released dosage for potency studies. The drugs active
solubility can be analyzed by UV or HPLC.
We follow the drug dissolution protocols of
USP, JP, BP, or European pharmacopean.
AAL can perform the following:
- USP <711> Apparatus 1 setup for capsule with
basket attached.
- USP <711> Apparatus 2 setup for tablet dissolution.
- Temperature control to 37°C, set up to follow
USP monograph or customer protocol.
- USP <724> Extended - Release apparatus 1 + 2
- USP <724> Reciprocating Cylinder
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Please contact
us if you have any questions about our dissolution testing
procedures, or if you require any special services. To request
a service, please download and send us a request
form.
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